What a single electroencephalographic (EEG) channel can tell us about Alzheimer's disease patients with mild cognitive impairment

Background Abnormalities in the neurophysiological oscillatory mechanisms generating dominant resting-state eyes closed electroencephalographic (rsEEG) rhythms portray Alzheimer’s disease (AD) continuum, from preclinical to dementia stage. Here, we tested whether these abnormalities may be reproducible by analyzing rsEEG signals acquired bipolar configuration with a montage consisting of only four centro-parietal and parieto-occipital channels (C3-P3, C4-P4, P3-O1, P4-O2) patients mild cognitive impairment (MCI) due AD (ADMCI). Method To evaluate study hypotheses, clinical, neuropsychological, anthropometric, genetic, cerebrospinal fluid (CSF), MRI, data 70 Nold 75 ADMCI subjects an international archive were used present study. The subgroups matched for age, gender, education. In all subjects, recordings lasted about 3-5 minutes. recorded sampling frequency 128-512 Hz related antialiasing bandpass between 0.01 60-100 Hz. Electrode included 19 scalp monopolar sensors placed following 10-20 System. investigated at individual delta, theta, alpha bands as well fixed beta (14-30 Hz) gamma (30-40 bands. Result Results confirmed previous evidence compared subjects. Moreover, group, group showed increased delta power density decreased C3-P3, P4-O2 channels. Increased theta was observed C3-P3 channel. Best classification accuracy individuals reached 81% (area under receiver operating characteristic curve) using Alpha2/Theta computed Conclusion current findings provide potential use low-channel portable devices topographic biomarker decline within extensive screening elderly population risk developing AD- or other dementia-related disorders. confirmation this hypothesis would have exciting applications framework telehealth home monitoring global brain functions.